Gene Duplication-Driven Evolution
Charles Darwin‘s first reference to a “gene” appears in the 4th Edition of The Origin of Species in 1866. Since then, the gene has emerged as the essential molecular mechanism driving Darwin’s theory.
This intersection of natural selection with Gregor Mendel‘s theory of genetic inheritance was later known as the Modern Evolutionary Synthesis, also referred to as The Modern Synthesis, primarily based on Julian Huxley’s 1942 book, Evolution: The Modern Synthesis.
A gene mutation-driven evolution theory gained increasing popularity. However, by the 1960s, the model began encountering challenges as it was being applied using emerging genomic technologies.